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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRPF8
All Species:
22.73
Human Site:
S2205
Identified Species:
41.67
UniProt:
Q6P2Q9
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6P2Q9
NP_006436.3
2335
273600
S2205
K
I
M
A
D
N
P
S
W
D
G
E
K
T
I
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001117328
2324
271913
T2195
L
S
P
Q
D
V
T
T
H
A
K
I
M
A
D
Dog
Lupus familis
XP_868467
2335
273550
S2205
K
I
M
A
D
N
P
S
W
D
G
E
K
T
I
Cat
Felis silvestris
Mouse
Mus musculus
Q99PV0
2335
273598
S2205
K
I
M
A
D
N
P
S
W
D
G
E
K
T
I
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_415805
2335
273614
S2205
K
V
M
A
D
N
P
S
W
D
G
E
K
T
I
Frog
Xenopus laevis
NP_001080253
2335
273603
A2205
K
V
M
A
D
N
P
A
W
D
G
E
K
T
I
Zebra Danio
Brachydanio rerio
NP_957270
2342
274356
S2212
K
V
M
A
D
N
P
S
W
D
G
E
K
T
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_610735
2396
279559
N2265
K
I
M
Q
E
N
S
N
W
D
G
E
K
T
I
Honey Bee
Apis mellifera
XP_624014
2374
277137
I2244
R
I
M
A
E
N
P
I
W
D
G
E
K
T
I
Nematode Worm
Caenorhab. elegans
P34369
2329
272009
S2198
K
L
L
T
D
N
I
S
W
D
G
E
K
T
V
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002327417
2357
275373
Q2227
R
V
L
E
N
N
K
Q
W
D
G
E
K
C
I
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_178124
2382
278110
Q2252
R
I
L
E
N
N
K
Q
W
D
G
E
K
C
I
Baker's Yeast
Sacchar. cerevisiae
P33334
2413
279485
D2283
T
H
S
K
L
F
A
D
K
K
R
D
C
I
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.1
99.7
N.A.
99.9
N.A.
N.A.
N.A.
99.4
98.5
97.6
N.A.
89.4
90.4
86.5
N.A.
Protein Similarity:
100
N.A.
98.5
99.8
N.A.
99.9
N.A.
N.A.
N.A.
99.6
99.4
99
N.A.
94.1
95.2
94.3
N.A.
P-Site Identity:
100
N.A.
6.6
100
N.A.
100
N.A.
N.A.
N.A.
93.3
86.6
93.3
N.A.
73.3
80
66.6
N.A.
P-Site Similarity:
100
N.A.
13.3
100
N.A.
100
N.A.
N.A.
N.A.
100
100
100
N.A.
86.6
93.3
86.6
N.A.
Percent
Protein Identity:
82.4
N.A.
N.A.
81.4
60.6
N.A.
Protein Similarity:
91.3
N.A.
N.A.
90.6
75.7
N.A.
P-Site Identity:
46.6
N.A.
N.A.
53.3
0
N.A.
P-Site Similarity:
73.3
N.A.
N.A.
73.3
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
54
0
0
8
8
0
8
0
0
0
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
8
16
0
% C
% Asp:
0
0
0
0
62
0
0
8
0
85
0
8
0
0
16
% D
% Glu:
0
0
0
16
16
0
0
0
0
0
0
85
0
0
0
% E
% Phe:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
85
0
0
0
0
% G
% His:
0
8
0
0
0
0
0
0
8
0
0
0
0
0
0
% H
% Ile:
0
47
0
0
0
0
8
8
0
0
0
8
0
8
77
% I
% Lys:
62
0
0
8
0
0
16
0
8
8
8
0
85
0
0
% K
% Leu:
8
8
24
0
8
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
62
0
0
0
0
0
0
0
0
0
8
0
0
% M
% Asn:
0
0
0
0
16
85
0
8
0
0
0
0
0
0
0
% N
% Pro:
0
0
8
0
0
0
54
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
16
0
0
0
16
0
0
0
0
0
0
0
% Q
% Arg:
24
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% R
% Ser:
0
8
8
0
0
0
8
47
0
0
0
0
0
0
0
% S
% Thr:
8
0
0
8
0
0
8
8
0
0
0
0
0
70
0
% T
% Val:
0
31
0
0
0
8
0
0
0
0
0
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
85
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _